Just 60 miles north of San Francisco sits the gorgeous town of St. Helena—one of Napa Valley Wine Country’s most sophisticated stopping points. Given its central location in the Napa Valley and many options for luxury resorts, historic hotels, and cozy inns, St. Helena is a perfect home base after a long day of wining and dining at the surrounding vineyards.

With stellar amenities like award-winning spas, yoga studios, restaurants, and more, here’s our roundup of some of our favorite places to stay when in or around St. Helena. Get to packing!

Meadowood Napa Valley

900 Meadowood Lane, St. Helena, CA 94574, (707) 967-1200

Luxury and seclusion make Meadowood Napa Valley a romantic lodging option for your next Wine Country escape. Located a few minutes off the Silverado Trail, Meadowood offers a true getaway for visitors, where stunning grounds, woods, and lush vineyards are all within eyeshot. Resort amenities—such as tennis courts, a fitness center, three pools, and a spa—will help you while away the hours, while their on-site restaurant will have you dining on delicious fare any time of day.

Insider Tip: The hotel’s property offers several hiking opportunities nearby; in fact, a three-mile trail with stunning views of the valley begins at Meadowood. Bring the hiking boots, though, as the path can get mossy.

Wydown Hotel

1424 Main Street, St. Helena, CA 94574, (707) 963-5100

Wydown Hotel is a luxury boutique hotel located in downtown St. Helena and boasts a chic, modern vibe. The hotel’s 12 rooms have a fresh, sophisticated look, yet remain comfortable and inviting. The “Living Room” lobby also encourages relaxation with its leather couches, TV, board games, and books, where guests like to lounge while sharing the stories from their days. Make new friends, and then walk to a nearby restaurant for dinner or a nightcap.

Insider Tip: The hotel is a five-minute walk from the Robert Louis Stevenson Museum at the St. Helena Public Library Center. For a nice change of pace, wander over to learn about the life of the famed writer of Treasure Island.

Alila Napa Valley

1915 Main Street, St. Helena, CA 94574, (707) 963-7000

Part historic Georgian farmhouse and part sprawling Wine Country resort, Alila Napa Valley is one of the newest luxury accommodations in St. Helena. A dozen different room and suite options are available and are outfitted with streamlined Italian furnishings, in-room soaking tubs, and private outdoor areas with fire pits. Wake up and call it a day next to the picturesque, neighboring Beringer Vineyards, take a dip in the shimmering pool, and be sure to enjoy a meal at their beautiful on-site restaurant, Violetto, where Italy meets the best of Napa Valley.

Insider Tip: Don’t drop your personal wellness goals during your stay. The hotel offers not only fitness classes, but also a world-class spa to soothe and combat stress. Spa Alila has a robust massage menu that includes Eastern and Western options, along with aroma blending, facials, and even full weekend retreats.

Harvest Inn

1 Main Street, St. Helena, CA 94574, (707) 963-9463

With its fantastical natural setting under towering Redwood trees and among gorgeous grapevines, it’s easy to see why St. Helena’s Harvest Inn earned a top spot in the Travel + Leisure Readers’ 15 Favorite Resorts in California, 2023. While there’s no on-site spa, Harvest Inn has teamed up with Health Spa Napa Valley, located just one mile north of the resort, to offer massages, treatments, and more. Got a gear head on your hands? Guests can even pick a Porsche or other luxury vehicle from the lot to cruise through Wine Country in style.

Insider Tip: For the cigar enthusiast, the Harvest Inn hosts a monthly Cigar Dinner Series on Thursdays, complete with live music, wine and cigar tasting, and farm-to-table cuisine.

The Ink House

1575 St. Helena Highway, St. Helena, CA 94574

Originally built in 1885 by California pioneer Theron H. Ink, the historic Ink House has since been reimagined as a luxurious inn where timeless elegance meets curated experiences. With only four exquisitely designed guest rooms, each uniquely appointed to reflect the property’s storied past, guests are treated to an intimate and bespoke stay. Signature offerings include exclusive aperitifs and digestifs with owners Jean-Charles Boisset and Gina Gallo-Boisset, immersive wine tastings, and private guided tours, all thoughtfully crafted to celebrate the art of hospitality and Napa Valley’s rich heritage.

Insider Tip: Fan of Elvis? Then book the Elvis Room, which features houndstooth pillows, flashy details, and Elvis movie posters and photos adorning the walls. What’s the Elvis connection, you ask? He made the historic building his home while filming “Wild in the Country” in 1960.